stem cell treatment for spinal cord injury

Kanno H, Pearse DD, Ozawa H, Itoi E, Bunge MB.

Role of endogenous Schwann cells in tissue repair after spinal cord injury. Zhang SX, Huang F, Gates M, Holmberg EG.Human muscle-derived stem/progenitor cells promote functional murine peripheral nerve regeneration. Lavasani M, Thompson SD, Pollett JB, et al.Neural stem cells promote nerve regeneration through IL12-induced Schwann cell differentiation. Mesenchymal stem cells enhance nerve regeneration in a rat sciatic nerve repair and hindlimb transplant model. Cooney DS, Wimmers EG, Ibrahim Z, et al.Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. Keirstead HS, Nistor G, Bernal G, et al.Transplantation of human embryonic stem cell-derived oligodendrocyte progenitors into rat spinal cord injuries does not cause harm. Cloutier F, Siegenthaler MM, Nistor G, Keirstead HS.Recovery from paralysis in adult rats using embryonic stem cells. Deshpande DM, Kim YS, Martinez T, et al.Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Ramon-Cueto A, Cordero MI, Santos-Benito FF, Avila J.Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Brustle O, Jones KN, Learish RD, et al.Stem cell transplantation for peripheral nerve regeneration: current options and opportunities. Therapeutic interventions after spinal cord injury. Stem cell therapy - Hype or hope? A review. Neurotrophic factors and gene therapy in spinal cord injury. Neurotrophic factors, cellular bridges and gene therapy for spinal cord injury. Jones LL, Oudega M, Bunge MB, Tuszynski MH.Neural stem cell therapy and rehabilitation in the central nervous system: emerging partnerships. Ross HH, Ambrosio F, Trumbower RD, Reier PJ, Behrman AL, Wolf SL.Current options for cell therapy in spinal cord injury. Vismara I, Papa S, Rossi F, Forloni G, Veglianese P.Stem cell therapies for spinal cord injury. Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Murray KC, Nakae A, Stephens MJ, et al.Restoration of sensorimotor functions after spinal cord injury. Spinal Cord Medicine: Principles and Practice. Chronic complications of spinal cord injury. Acute complications of spinal cord injuries. Birmingham, AL: University of Alabama at Birmingham 2015:1-2. Epidemiology of worldwide spinal cord injury: a literature review. Kang Y, Ding H, Zhou H, Wei ZJ, Liu L, Pan DY, et al.Acute spinal cord injury: A review of pathophysiology and potential of non-steroidal anti-inflammatory drugs for pharmacological intervention. This article briefly discusses the treatment of SCI by cell transplantation and the benefits of using Mesenchymal stem cells as an alternative for SCs. Accordingly, many studies demonstrated that mesenchymal cells are well suited for cell therapy of SCI. These cells can be transdifferentiated into SC-like cells in neuronal induction media. They are as easily accessed source with high growth rate and low immunogenicity therefore, these properties make them an interesting source for cell therapy. Mesenchymal stem cells can differentiate to various type cells. However, the use of stem cells to differentiate into SCs can reduce the risks associated with the use of mature cells in the grafting process. Transplantation of Schwann cells (SCs) has shown a great promising result for SCI but harvesting SC is limited due to donor complications and limited cell collection capacity. Cell transplantation is one of the remarkable strategies for the treatment of spinal cord injury. Spinal cord injury (SCI) is one of the most severe types of disabilities that has a limited capacity to repair therefore, medical interventions are essential to the treatment of injuries.

Stem cell treatment for spinal cord injury